•• Films & Television Series
* 1983: Class as Lisa
* 1984: Electric Dreams as Madeline Robistat
* 1984: Dune as Princess Irulan
* 1985: Creator as Barbara Spencer
* 1986: Fire with Fire as Lisa Taylor
* 1986: Modern Girls as Kelly
* 1987: Slam Dance as Yolanda Caldwell
* 1987: Zombie High as Andrea
* 1987: Long Gone as Dixie Lee Boxx
* 1988: Gotham as Rachel Carlyle
* 1988: Mr. North as Sally Boffin
* 1988: Hot to Trot as Allison Rowe
* 1989: Heart of Dixie as Delia June Curry
* 1990: The Hot Spot as Dolly Harshaw
* 1991: Victim of Love as Carla Simons
* 1991: Becoming Colette as Polaire
* 1991: Highlander II: The Quickening as Louise Marcus
* 1991: Ironclads as Betty Stuart
* 1992: A Murderous Affair: The Carolyn Warmus Story as Carolyn Warmus
* 1992: Candyman as Helen Lyle
* 1994: Caroline at Midnight as Susan Prince
* 1994: Blue Tiger as Gina Hayes
* 1995: The Prophecy as Katherine
* 1996: Just Your Luck as Kim
* 1996: Just Ask My Children as Brenda Kniffen
* 1996: Ghosts of Mississippi as Dixie DeLaughter
* 1997: The Rainmaker as Jackie Lemancyzk
* 1998: Ballad of the Nightingale as N/A
* 1998: Ambushed as Lucy Monroe
* 1999: The Florentine as Molly
* 1999: The Haunting as Jane
* 2000: Lying in Wait as Vera Miller
* 2000: Children of Fortune as Ingrid Bast
* 2000: After Sex as Traci
* 2001: Crossfire Trail as Anne Rodney
* 2001: Full Disclosure as Brenda Hopkins
* 2001: Almost Salinas as Clare
* 2001: Just Ask My Children as Brenda Kniffen
* 2002: American Gun as Penny Tillman
* 2003: Artworks as Emma Becker
* 2003: Nobody Knows Anything! as Prison Lawyer
* 2003: CSI: Miami as Krista Walker (1 episode)
* 2003: Tempted as Emma Burke
* 2004: Sideways as Maya
* 2004: Brave New Girl as Wanda Lovell
* 2006: Smith as Hope Stevens (7 episodes, 2006-07)
* 2006: Firewall as Beth Stanfield
* 2006: A Prairie Home Companion as Dangerous Woman
* 2007: The Astronaut Farmer as Audrey ‘Audie’ Farmer
* 2007: Ripple Effect as Sherry
* 2007: The Number 23 as Agatha Sparrow / Fabrizia
* 2008: Diminished Capacity as Charlotte
* 2009: The Haunting in Connecticut as Sara Campbell
* 2009: Monk as T.K. Jensen (3 episodes)
* 2009: Amelia as Dorothy Binney (her scenes were cut)
* 2010: Father of Invention as Lorraine
* 2010: Scoundrels as Cheryl West
* 2011: Red Riding Hood as Suzette
* 2011: The Event as Senator Catherine Lewis
* 2012: Hornet’s Nest as Judy Hammer
* 2012: The Magic of Belle Isle as Mrs. O’Neil
* 2012: Jan as Mel Karpova
* 2012: Hell on Wheels as Hannah Durant
* 2012: Ruth and Erica as Mel Karpova
* 2012: Hatfields & McCoys as Eloise McCoy (show not picked up)
* 2013: The Magic of Belle Isle as Mrs. O’Neil
* 2013: Susanna Mel Karpova
* 2013: Anna Nicole Virgie Arthur
* 2013: Jake Squared as Beth
* 2013: The Last Keepers as Abigail Carver
* 2013: Crazy Kind of Love as Augusta Iris
* 2013: The Hot Flashes as Clementine Winks
* 2013: Jake Squared as Beth
* 2013: Witches of East End as Penelope Gardiner
* 2015: All the Wilderness as Abigail Charm
* 2015: Babylon Fields as Rhonda Wunch
* 2015: Walter as Karen
* 2015: Dead Rising: Watchtower as Maggie
* 2015: American Girl: Grace Stirs Up Success as Mrs. Thomas
* 2015: The Lost Boy as Laura Harris
* 2015: Law & Order: Special Victims Unit as Beth Anne Rollins
* 2015: Joy as Terry
* 2016: Burning Bodhi as Naomi
* 2016: Road to Capri as Katherine
* 2016: Burn Your Maps as Victoria
* 2016: Better Watch Out as Deandra Lerner
* 2016: American Gothic as Madeline Hawthorne
* 2016-2017: Designated Survivor as Honorable Congresswoman Kimble Hookstraten
* 2017: Voltron: Legendary Defender as Commander Heera
* 2017: A Change of Heart as Deena
* 2018: 1985 as Eileen
* 2018: Her Smell as Ania Adamcyzk
* 2018: Spare Room as Nat
* 2018: The Truth About the Harry Quebert Affair as Tamara Quinn
* 2016-2019: Elementary as Paige Cowen
* 2020: Swamp Thing as Maria Sunderland
* 2020: Operation Christmas Drop as Congresswoman Angie Bradford
* 2021: The Devil’s Light as Dr. Peters

•• Short Films
* 2007: Cutlass as Robin
* 2011: Funny or Die – Episode: Marriage Drama with Virginia Madsen as Virginia/Linda

•• Documentaries
* 2007: Being Michael Madsen as Herself
* 2009: I Know A Woman Like That (Produced and Narrated by Virginia)
* 2011: Fighting Gravity (Executive Producer)

•• Voice Work
* 2005: Teen Titans as Arella
* 2005: Stuart Little 3: Call of the Wild as The Beast
* 2005: Scooby Doo! “Where’s My Mummy?” as Cleopatra
* 2002, 2005 & 2006: Justice League as Dr. Sarah Corwin & Roulette
* 2009: Wonder Woman Hippolyta